A de novo marker chromosome 15 in a child with isolated developmental delay

Kumar, Madhavan JeevanGowrishankar, KalpanaHemagowri, VenkatasubramanianKadandale, Jayarama2020-11-182020-11-182020-09Kumar Madhavan Jeevan, Gowrishankar Kalpana, Hemagowri Venkatasubramanian, Kadandale Jayarama. A de novo marker chromosome 15 in a child with isolated developmental delay. Journal of Genetics. 2020 Sep; 99: 1-40022-13330973-7731http://imsear.searo.who.int/handle/123456789/215488We report a rare case of a 14-month-old male child who was referred for developmental delay. Clinical examination revealed a hypotonic infant with speech delay and no dysmorphic features. The banding cytogenetics revealed a small supernumerary marker chromosome. Upon silver staining, the marker showed the presence of satellite regions on either ends. Further, analysis using fluorescence in situ hybridization on marker chromosome revealed its origin from chromosome 15.cytogeneticssatellite chromosomefluorescence in situ hybridizationmarker chromosomeuniparental disomyA de novo marker chromosome 15 in a child with isolated developmental delayJournal ArticleIndiaDepartment of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur 603 203, IndiaDepartment of Medical Genetics, CHILDS Trust Medical Research Foundation (CTMRF), Kanchi Kamakoti CHILDS Trust Hospital, Chennai 600 034, IndiaDepartment of Medical Genetics, CHILDS Trust Medical Research Foundation (CTMRF), Kanchi Kamakoti CHILDS Trust Hospital, Chennai 600 034, IndiaDepartment of Molecular Cytogenetics, Centre for Human Genetics, Bengaluru 560 100, India