Gaur, AKhan, MI.2025-05-092025-05-092024-09Gaur A, Khan MI.. Clinical Significance of Microbial Flora in Middle Ear Infections and its Implications . International Archives of BioMedical and Clinical Research. 2024 Sep; 10(3): MB1-MB32454-98942454-9886https://imsear.searo.who.int/handle/123456789/242635Background: In pre-antibiotic era, complications related with CSOM were frequent, but, the antibiotics is important to clinicians as a tool to be used even without the specific etiological diagnosis. However, if the antibiotics used wide in range so it leads to the emergence of multi-drug resistant bacterial strains and complication of disease. In the last decade, variations in microbial flora in middle ear infection have been confirmed by many researchers. Methods: This study was carried out in 110 cases who had middle ear infection. This study was conducted in the Department of Microbiology and Otolaryngology, Government Medical College, Shahdol. This study duration was six month. Results: We found that from the 53.6% cases had infection with Gram positive bacteria followed by gram negative bacteria. Conclusions: This is suggested that ear infection should be treated when the causative agents as well as the drug sensitivity patterns are known and properly administered.MicroorganismCSOMAntibiotic susceptibility testJournal ArticleIndiaAssociate Professor, Department of Microbiology, Government Medical College, ShahdolAssistant Professor, Department of Otolaryngology, Government Medical College, Shahdol