Agrawal, VinodNanda, Saurav NarayanTripathi, SanjayShah, Munjal SatishLakhani, KarmeshAgrawal, AniruddhaParmar, Himanshu2016-10-142016-10-142016-09Agrawal Vinod, Nanda Saurav Narayan, Tripathi Sanjay, Shah Munjal Satish, Lakhani Karmesh, Agrawal Aniruddha, Parmar Himanshu. Recombinant Human Bone Morphogenic Protein-2 (BMP-2): A Newer & Novel Osteoinductive Treatment Modality for Non-union of Bones. Annals of International Medical and Dental Research. 2016 Sept-Oct; 2(5): 40-46.http://imsear.searo.who.int/handle/123456789/177827Background: The non-union of bones is a multifactorial phenomenon. In this study, it was emphasized to evaluate the efficacy and safety of bone morphogenetic protein-2 (BMP-2) as a bone-stimulating agent in the treatment of non-unions. Methods: Fifteen patients [5 males, mean age 51.06 years (range: 21—75)] with sixteen non-unions were treated with BMP-2. There were eleven femoral non-union, three humerus, one ulna, one distal fibula non-union. The mean follow-up was 22.06 months. Results: Both clinical and radiological union occurred in 15 (93.75%) non unions cases. Radiological union achieved within a mean time of 15.75 weeks. The remaining one show incomplete union with recalcitrant formation was asymptomatic and having good pain free range of movement, declines further intervention. No complications or adverse effects from the use of BMP-2 were encountered. Conclusion: In this study, it was observed that BMP-2 is a powerful adjunct and one of the safe armamentarium for the surgeon to handle difficult and challenging clinical conditions.enNon-unionsBMP-2Growth factorsArticle