Gill, H HDesai, H GMajmudar, PMehta, P RPrabhu, S R1993-01-012009-05-291993-01-012009-05-291993-01-01Gill HH, Desai HG, Majmudar P, Mehta PR, Prabhu SR. Epidemiology of Helicobacter pylori: the Indian scenario. Indian Journal of Gastroenterology. 1993 Jan; 12(1): 9-11http://imsear.searo.who.int/handle/123456789/63969OBJECTIVE: To compare the age-related prevalence of Helicobacter pylori in populations from developing and developed nations to determine the possible mode of transmission. METHODS: Endoscopic gastric biopsies (for biopsy urease test and histology) were obtained in 526 patients with dyspepsia and in 82 control subjects to determine H pylori prevalence. RESULTS: H pylori prevalence in patients with dyspepsia and in control subjects was 65% and 46% respectively. Age-related prevalence in these two groups in the age groups 10-19 years, 20-29 years, 30-39 years, 40-49 years and > or = 50 years was 52%, 70%, 69%, 60% and 59%, and 44%, 55% 58%, 36% and 33% respectively. CONCLUSION: Exposure to H pylori occurs early in India and is widespread, even in control subjects. The high prevalence of the organism in young Indian control subjects and the comparable prevalence of antibodies to H pylori and hepatitis A virus infection in different age groups both in developed and developing nations may suggest a feco-oral mode of transmission.engAdolescentAdultAge FactorsAgedBiopsyChildDeveloping CountriesDyspepsia --complicationsFemaleGastroscopyHelicobacter Infections --epidemiologyHelicobacter pylori --isolation & purificationHumansIndia --epidemiologyMaleMiddle AgedPrevalenceComparative Study