Jain, Narender PalGupta, ShwetaSingla, Sanjeev KumarBudhiraja, SanchitMahajan, Rajesh2014-06-282014-06-282013-07Jain Narender Pal, Gupta Shweta, Singla Sanjeev Kumar, Budhiraja Sanchit, Mahajan Rajesh. Prospective study of the clinical profile of hospitalized patients of malaria. National Journal of Integrated Research in Medicine. 2013 Jul-Aug; 4(4): 92-97.http://imsear.searo.who.int/handle/123456789/152393Background & Objectives: To study the clinical profile of hospitalised patients of malaria aged 15-60 years. Methods: This was a prospective analysis of patients suffering from malaria diagnosed by malaria serology and/or peripheral smear. The mode of presentation, clinical course, treatment history, laboratory investigations and complications were recorded and the data statistically analyzed.Results: P. vivax was the most common (80.39%) plasmodium species, the rest (19.61%) being P. falciparum. The mortality rate was 6.54%. A fall in hemoglobin (p=0.005) and platelet count (p=0.040) was observed in the patients who expired. There was an improvement in the final platelet counts in both the groups (p=0.00052). The mean total bilirubin at admission was higher in P. falciparum group than P. vivax group (p = 0.00789). Renal failure was observed in 16.34% patients. The mean systolic and diastolic blood pressure in patients who expired was lower than patients who were discharged (p=0.007, 0.001). The mean heart rate was higher (109.40) in patients who expired (p = 0.002). Conclusion: Factors associated with poor prognosis in malaria are moderate grade fever, hypotension, tachycardia, anaemia, thrombocytopenia, hyperbilirubinemia, high transaminase and renal failure. A high clinical suspicion, early diagnosis and treatment is recommended in highly prone areas.enMalariaPlasmodium falciparumPlasmodium vivaxArticle