Mehta, VPuri, RDuell, PBIyengar, S SWong, Nathan, DYusuf, JamalMukhopadhyay, SaibalPradhan, AkshayaMuruganathan, ArumugamWangnoo, S KKapoor, DheerajRastogi, AshuTiwaskar, Mangesh HMahajan, KunalNarasingan, S NAgarwala, RajeevBordoloi, NeilSoumitra, KumarChakraborty, RabinShetty, SadanandSaboo, BansiKhan, AzizPrabhakar, DKhanna, Narendra NathMehta, AshwaniBansal, ManishKasliwal, RaviMehrotra, RahulChag, MilanSheikh, AltameshSattur, Gururaj BalvantraoManoria, P CPareek, K KPancholia, A KMelinkeri, Rashida PatanwalaNanda, RashmiKalra, Dinesh2023-06-172023-06-172022-09Mehta V, Puri R, Duell PB, Iyengar S S, Wong Nathan D, Yusuf Jamal, Mukhopadhyay Saibal, Pradhan Akshaya, Muruganathan Arumugam, Wangnoo S K, Kapoor Dheeraj, Rastogi Ashu, Tiwaskar Mangesh H, Mahajan Kunal, Narasingan S N, Agarwala Rajeev, Bordoloi Neil, Soumitra Kumar, Chakraborty Rabin, Shetty Sadanand, Saboo Bansi, Khan Aziz, Prabhakar D, Khanna Narendra Nath, Mehta Ashwani, Bansal Manish, Kasliwal Ravi, Mehrotra Rahul, Chag Milan, Sheikh Altamesh, Sattur Gururaj Balvantrao, Manoria P C, Pareek K K, Pancholia A K, Melinkeri Rashida Patanwala, Nanda Rashmi, Kalra Dinesh. Unmet Need for Further LDL-C Lowering in India despite Statin Therapy: Lipid Association of India Recommendations for the Use of Bempedoic Acid. Journal of the Association of Physicians of India. 2022 Sep; 70(9): 67-750004 – 5772http://imsear.searo.who.int/handle/123456789/216256Lipid-lowering therapy plays a crucial role in reducing adverse cardiovascular (CV) events in patients with established atherosclerotic cardiovascular disease (ASCVD) and familial hypercholesterolemia. Lifestyle interventions along with high-intensity statin therapy are the first-line management strategy followed by ezetimibe. Only about 20–30% of patients who are on maximally tolerated statins reach recommended low-density lipoprotein cholesterol (LDL-C) goals. Several factors contribute to the problem, including adherence issues, prescription of less than high-intensity statin therapy, and de-escalation of statin dosages, but in patients with very high baseline LDL-C levels, including those with familial hypercholesterolemia and those who are intolerant to statins, it is critical to expand our arsenal of LDL-C-lowering medications. Moreover, in the extreme risk group of patients with an LDL-C goal of ?30 mg/dL according to the Lipid Association of India (LAI) risk stratification algorithm, there is a significant residual risk requiring the addition of non-statin drugs to achieve LAI recommended targets. This makes bempedoic acid a welcome addition to the existing non-statin therapies such as ezetimibe, bile acid sequestrants, and PCSK9 inhibitors. A low frequency of muscle-related side effects, minimal drug interactions, a significant reduction in high-sensitivity C-reactive protein (hsCRP), and a lower incidence of new-onset or worsening diabetes make it a useful adjunct for LDL-C lowering. However, the CV outcomes trial results are still pending. In this LAI consensus document, we discuss the pharmacology, indications, contraindications, advantages, and evidence-based recommendations for the use of bempedoic acid in clinical practice.Journal ArticleIndiaChair, Director-Professor, Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New DelhiCo-chair, Senior Consultant Cardiologist, Indraprastha Apollo Hospitals, New Delhi, Delhi, IndiaCo-chair, Professor of Medicine and Director, Cardiovascular Institute and Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon, USASr. Consultant, Department of Cardiology, Manipal Hospitals, Bengaluru, Karnataka, IndiaProfessor and Director, Heart Disease Prevention Program Division of Cardiology, University of California Irvine, Irvine, California, USADirector-ProfessorDirector-Professor and Head, Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, DelhiSr. Consultant, Department of Cardiology, King George’s Medical University, Lucknow, Uttar PradeshSr. Consultant, Department of Internal Medicine, AG Hospital, Tirupur, Tamil NaduSr. Consultant Endocrinologist & Diabetologist, Indraprastha Apollo Hospitals, New Delhi, DelhiHead, Department of Endocrinology, Artemis Hospital, Gurugram, HaryanaAssistant Professor, Department of Endocrinology and Metabolism, Postgraduate Institute of Medical Education and Research, Chandigarh, PunjabConsultant Physician and Dialectologist, Shilpa Medical Research Centre, Mumbai, MaharashtraAssistant Professor, Department of Cardiology, Indira Gandhi Medical College & Hospital, Shimla, Himachal PradeshFormer Adjunct Professor, Department of Medicine, The Tamil Nadu Dr. M.G.R. Medical UniversityManaging Director, SNN Specialities Clinic, Chennai, Tamil NaduSr. Consultant Cardiologist, Jaswant Rai Speciality Hospital, Meerut, Uttar PradeshManaging Director and HOD, Department of Cardiology, Excelcare Hospitals, Guwahati, AssamProfessor and Head, Department of Cardiology, Vivekananda Institute of Medical Sciences, Kolkata, West BengalConsultant Cardiologist, Kokilaben Dhirubhai Ambani Hospital & Medical Research InstituteDirector, Centre for Cardiac SciencesHead, Department of Cardiology, KJ Somaiya Hospital Super Speciality Center, Mumbai, MaharashtraChief Diabetologist & Chairman, Dia-Care Diabetes Care & Hormone Clinic, Ahmedabad, GujaratSr. Consultant Cardiologist, Crescent Hospital & Heart Centre, Nagpur, MaharashtraSr. Consultant, Department of Cardiology, Apollo Hospitals, Chennai, Tamil NaduSr. Consultant, Department of Cardiology, Indraprastha Apollo HospitalsSr. Consultant Cardiologist, Sir Ganga Ram Hospital, New Delhi, DelhiAssociate Director, Department of CardiologyChairman, Division of Clinical & Preventive Cardiology, Medanta Hospital, Gurugram, HaryanaDirector & Head, Department of Non-invasive Cardiology, Max Super Speciality Hospital, New Delhi, DelhiInterventional Cardiologist & Managing Director, Marengo CIMS, Ahmedabad, GujaratSr. Consultant, Department of Endocrinology, Saifee Hospital, Mumbai, MaharashtraSr. Consultant Physician and Diabetologist, Sattur Medical Care, Hubli, KarnatakaDirector, Manoria Heart and Critical Care Hospital, Bhopal, Madhya PradeshHead, Department of Medicine, S. N. Pareek Hospital, Kota, RajasthanHead of Department, Department of Medicine & Preventive Cardiology, Arihant Hospital & Research Centre, Indore, Madhya PradeshSr. Consultant, Department of Internal Medicine, Sahyadri Hospitals, Pune, MaharashtraConsultant Physician, Cardiac Care Centre, New Delhi, Delhi, IndiaAssociate Professor, Department of Medicine, Rush Medical College, Rush Medical College, USA