Guo, YongZhang, Hai-CongXue, ShengZheng, Jun-Hua2020-11-182020-11-182019-04Guo Yong, Zhang Hai-Cong, Xue Sheng, Zheng Jun-Hua. Receptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinoma. Journal of Cancer Research and Therapeutics. 2019 Apr; 15(2): 317-3230973-1482http://imsear.searo.who.int/handle/123456789/213616Background: The receptor for advanced glycation end-product (RAGE) was one of the signal transduction receptors. RAGE interacted with various signaling molecules which were involved in human disease processes including tumorigenesis. Previous reports have indicated that RAGE/high-mobility group box 1 (HMGB1) could regulate autophagy in different carcinomas. However, the functional role of RAGE/ HMGB1 in the regulation of clear cell renal cell carcinoma (ccRCC) autophagy remained unrevealed. Methods: Western blot, quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence were used in the present study. Results: In this study, we demonstrated that the levels of RAGE/HMGB1 and autophagic protein LC3, Beclin-1, PI3K were much higher in ccRCC samples than those of in adjacent normal tissues. RAGE and autophagic protein expression was regulated with RAGE/HMGB1 in human RCC cell lines. Conclusion: Our results implicated that RAGE and autophagy played important roles in ccRCC, and RAGE/HMGB1 might serve as a novel therapeutic target for future ccRCC treatmentAutophagyclear cell renal cell carcinomahigh-mobility group box 1receptor for advanced glycation end-productReceptors for advanced glycation end products is associated with autophagy in the clear cell renal cell carcinomaJournal ArticleIndiaDepartment of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing; Transplantation Centre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pathology, The Fifth Hospital of Shijiazhuang, Shijiazhuang, ChinaDepartment of Urology, Shanghai Tenth People's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, Shanghai General Hospital of Nanjing Medical University, Nanjing; Department of Urology, The Affiliated First People's Hospital of Shanghai Jiao Tong University, Shanghai, China