Behera, BijayiniTripathy, SwagataVenkateshan, MahalingamMahapatra, AshokaMohanty, SrujanaGupta, KavitaMishra, BaijayantimalaRao, P BhaskarMitra, Jayanta KumarMohapatra, Prasanta RaghabPanigrahi, Manoj KumarBhuniya, SourinBal, Shakti Kumar2023-06-172023-06-172022-02Behera Bijayini, Tripathy Swagata, Venkateshan Mahalingam, Mahapatra Ashoka, Mohanty Srujana, Gupta Kavita, Mishra Baijayantimala, Rao P Bhaskar, Mitra Jayanta Kumar, Mohapatra Prasanta Raghab, Panigrahi Manoj Kumar, Bhuniya Sourin, Bal Shakti Kumar. Spectrum of Bacterial Pathogens in Critical COVID-19 Patients Admitted in Intensive Care Units of a Tertiary Care Hospital During the First and Second Wave of the Pandemic. Journal of the Association of Physicians of India. 2022 Feb; 70(2): 28-31a0004 – 5772http://imsear.searo.who.int/handle/123456789/216129Objective: This study intends to compare the clinical characteristics and the prevalence and spectrum of bacterial pathogens in COVID-19 patients admitted to ICU during the first and second waves at a tertiary care, teaching and referral hospital of eastern India. Method: This is a hospital-based retrospective study which analysed demographic details, clinical profile and bacterial culture results of severe and critically ill COVID-19 patients admitted in intensive care units (ICU) during April -Oct 2020 (1 st wave) and April –July 2021 (2 nd wave). Result: The patients admitted during the 2 nd wave were comparatively older and had multiple comorbidities compared to the 1 st wave. (23.8%) (45/189) and 50% (173/346) of the COVID-19 patients admitted to ICU developed bacterial infection during the 1 st and 2 nd wave respectively. Overall, there was predominance of multidrug resistant Gram negative bacilli in both the waves. There was increased isolation of intrinsic colistin resistant microorganisms. Conclusion: Multidrug resistant Gram negative bacterial infections, remain a dreaded complication in severe and critically ill hospitalised COVID-19 patients requiring ICU care and high usage of colistin spirals the emergence and spread of pathogens intrinsically resistant to colistin.Journal ArticleIndiaAdditional Professor, Department of MicrobiologyAdditional Professor, Department of AnaesthesiologyLecturer, Department of NursingAssistant ProfessorProfessor, Department of MicrobiologyProfessorAdditional ProfessorAssistant Professor, Department of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha