Mageed, Ahmad M. AbdelOsman, Ahmed Kamal EldinAwad, Nabil S.A.Abdein, Mohamed2020-09-242020-09-242019-01Mageed Ahmad M. Abdel, Osman Ahmed Kamal Eldin, Awad Nabil S., A.Abdein Mohamed. Evaluation of Antidiabetic Potentiality of Truffles and Balanites Aegyptiaca among Streptozotocin Induced Diabetic Rats. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 36-442277-3657http://imsear.searo.who.int/handle/123456789/203631The potential application of Truffle (Terfeziaceae) and Desert Date tree (Balanites aegyptiaca) for modulating the diabetesmellitus related symptoms has gained much interest. However, less firm evidence has come from data to increase theunderstanding of the mechanism by which Truffle and Balanites protect pancreatic β-cells. The present study aimed toevaluate the effect of methanolic extract of Truffle and Balanites aegyptiaca on the fasting blood glucose (FBG) level; thechanges in pancreatic histology as well as the changes in iNOS and IL-1β genes expression level among STZ induceddiabetic rats which might help in better clarification of possible mechanisms beside the beneficial effects of the studiedplants on diabetes. The elevation of the FBG level, pathological pancreatic changes and the level of both IL-1β and iNOSgene expressions in diabetic rats were observed in comparison with negative control rats. This increase was declinedsignificantly due to the administration of Truffle and Balanites extracts. All of the studied parameters did not completelyreverse to the normal levels as compared with negative control rats. The obtained results concluded that the beneficial effectof Truffle and Balanites aegyptiaca on STZ-induced diabetes was at least partly due to the reduction of IL-1β and iNOS geneover the expression which can have a protective effect on β cell.DiabetesRatsTrufflesBalanites AegyptiacaIL-1βiNOS.Journal ArticleIndiaBiology Department, Faculty of Arts and Science, Northern Border University, 91911 Rafha, Kingdom of Saudi Arabia.Zoology Department, Faculty of Science, Minia University, 61519 Minia, Egypt.Biology Department, Faculty of Science, Northern Border University, 91431 Arar, Kingdom of Saudi Arabia.Botany Dep., Fac. Sci., South Valley University, 83523 Qena, Egypt.Department of Genetics, Faculty of Agriculture and Natural Resources, Aswan University, 81528 Aswan,Egypt.College of Biotechnology, Misr University for Science and Technology, 12563 Giza, Egypt.