Rawool, AnupGupta, SatyaprakashSingh, BhartiPhadke, Shubha RSaxena, DeeptiMandal, Kausik2020-10-162020-10-162020-09Rawool Anup, Gupta Satyaprakash, Singh Bharti, Phadke Shubha R, Saxena Deepti, Mandal Kausik. Recurrent miscarriage in North Indian population: a study of association of polymorphisms in genes coding for the natural killer: cell receptor natural killer group 2, member D and its ligand MHC class I chain-related protein A. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2020 Sep; 9(9): 3665-36712320-17702320-1789http://imsear.searo.who.int/handle/123456789/207999Background: The objective of this present study was to investigate the possible association of natural killer group (NKG) receptors gene polymorphisms and MHC class I chain-related protein A (MICA) gene polymorphism with recurrent spontaneous abortion (RSA).Methods: Three single-nucleotide polymorphism (SNPs) in NKG2D gene (rs2255336, rs2617160 and rs2617170) and one SNP in MICA gene (MICA129) rs1051792 were assessed in 100 controls and 100 patients employing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis.Results: NKG2D (rs2617160) and MICA 129 (rs1051792) variants are associated with RSA risk in North Indian women.Conclusions: The NKG2D and MICA129 gene polymorphisms may influence the success of pregnancy in North Indian women population.MICA 129 geneNKG2D geneSingle-nucleotide polymorphismUnexplained recurrent spontaneous abortionJournal ArticleIndiaDepartment of Obstetrics and Gynecology, Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India