Chandrasekar, BMukherjee, S K1989-08-012009-05-271989-08-012009-05-271989-08-01Chandrasekar B, Mukherjee SK. Effects of prednisolone and dexamethasone on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans. Indian Journal of Biochemistry & Biophysics. 1989 Aug; 26(4): 278-9http://imsear.searo.who.int/handle/123456789/28502Administration of either prednisolone or dexamethasone (10 mg/kg body wt/day/oral) to rats for 21 days resulted in inhibition of (pro)insulin biosynthesis and immunoreactive insulin release by isolated islets. A gradual reversal of prednisolone's effect was obtained after exposing islets to increasing glucose concentrations but glucose challenges failed to influence dexamethasone's effect.engAnimalsDexamethasone --pharmacologyInsulin --secretionIslets of Langerhans --drug effectsMalePrednisolone --pharmacologyProinsulin --biosynthesisRatsJournal Article