Yadav, Raj KumarVerma, Nar Singh2009-05-282009-05-282004-06-21Yadav RK, Verma NS. Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose-dependent study. Indian Journal of Experimental Biology. 2004 Jun; 42(6): 628-31http://imsear.searo.who.int/handle/123456789/62541Garlic juice (dose equivalent to 3.3 g to 33 g garlic) mainly caused bradycardia in frog Rana tigerina. The disturbance in ventricular rhythm was observed prior to than that of atria. Rhythm was specially disturbed at higher doses causing bizarre pattern. Force of contraction of the heart also decreased with higher dose of the garlic extract. The results suggest that garlic extract has some beneficial effect on heart rate modulating the rate, rhythm and force of contraction positively but very high doses may exert non-desirable effects as well.engAnimalsDose-Response Relationship, DrugElectrocardiographyFree RadicalsGarlic --metabolismHeart --drug effectsHeart Rate --drug effectsModels, ChemicalMuscle ContractionMyocardial Contraction --drug effectsPlant ExtractsRanidaeJournal Article