Sundaram, VenkataseshanDutta, SourabhAhluwalia, JasminaNarang, Anil2013-01-082013-01-082009-09Sundaram Venkataseshan, Dutta Sourabh, Ahluwalia Jasmina, Narang Anil. Score for neonatal acute physiology II predicts mortality and persistent organ dysfunction in neonates with severe septicemia. Indian Pediatrics. 2009 Sept; 46(9): 775-780.http://imsear.searo.who.int/handle/123456789/144173Objective: To investigate the relationship between score for neonatal acute physiology II (SNAP II) applied within 12 hours from the onset of severe sepsis, and death and persistent organ dysfunction (OD). Design: Prospective cohort study. Setting: Level III neonatal intensive care unit. Participants: Neonates with severe sepsis. Intervention:SNAP II was applied within the first 12 hours from the onset of severe sepsis. Neonates with major malformations, severe asphyxia and prior blood products were excluded. Major outcome measure: Death at day 14 from enrolment. Results: Forty neonates completed the study. Twenty-five died within 14 days. The median SNAP II was significantly higher in babies who died versus those who survived [median (IQR): 43 (36 – 53.5) vs 18 (16 - 37), P<0.001]. A SNAP II greater than 40 had 88% positive predictive value for death and persistent OD each, and 86.6% and 86% specificity for death and persistent OD, respectively. On day 14 from enrolment, more organs normalized/improved in the subjects with SNAP II of £40. Perfusion related SNAP II parameters were significantly associated with death and organ dysfunction. Conclusions: Severely septicemic neonates with high SNAP II scores (>40) have a higher risk of dying and persistent organ dysfunction. Individual SNAP II parameters do not contribute equally in prediction of mortality.enMortalityNeonateOrgan dysfunctionSepsisSNAP IICohort StudiesHumansInfant, NewbornInfant, Newborn, Diseases --diagnosisInfant, Newborn, Diseases --pathologyIntensive Care Units, NeonatalMultiple Organ Failure --diagnosisMultiple Organ Failure --pathologyNeonatology --methodsProspective StudiesRisk AssessmentSepsis --diagnosisSepsis --pathologySeverity of Illness IndexSurvival AnalysisArticle