PASUPULATI, HSWATHI, BTAHSEEN, SANWER, MSSANDHYA, RFATHIMA, SFATIMA, SA.2025-05-122025-05-122024-12PASUPULATI H, SWATHI B, TAHSEEN S, ANWER MS, SANDHYA R, FATHIMA S, FATIMA SA.. AN OBSERVATIONAL STUDY OF PERIPHERAL NEUROPATHY IN DIABETES PATIENTS ON METFORMIN THERAPY AND THE ROLE OF VITAMIN B-12 SUPPLEMENTATION . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Dec; 16(12): 21-250975-14912656-0097https://imsear.searo.who.int/handle/123456789/246452Objective: This study aims to assess the prevalence of peripheral neuropathy in diabetic patients on metformin therapy using the Douleur Neuropathique 4 (DN-4) scale, explore the relationship between long-term metformin use and serum vitamin B-12 levels, and identify how metformin contributes to neuropathy. Additionally, it seeks to raise awareness about the importance of vitamin B-12 monitoring and supplementation for improving patient quality of life. Methods: An observational study was conducted involving diabetes patients on metformin therapy. Data were collected on patient demographics, clinical characteristics, and vitamin B-12 levels. Peripheral neuropathy was assessed using the DN-4 questionnaire. Correlations between metformin duration, dosage, vitamin B-12 levels, and neuropathy prevalence were analyzed. Results: The results indicated that the majority of the study population were male (61.2%) and aged 51-60 years (41.8%), with a majority proportion residing in urban areas (74%). A significant finding was that Peripheral neuropathy was prevalent in 44.8% of patients, with 51.5% exhibiting vitamin B-12 deficiency. Furthermore, the study identified a high prevalence of peripheral neuropathy with a significant correlation between longer metformin use and increased neuropathy (r =0.9372), additionally, a strong negative correlation between metformin dosage and Vitamin B-12 levels (r=-0.9189) highlighted the risk of deficiency with higher doses. Conclusion: The study underscores the critical role of monitoring and supplementing vitamin B-12 in diabetes patients on metformin therapy to mitigate peripheral neuropathy. Regular screening and proactive supplementation could potentially reduce neuropathic complications associated with long-term metformin use.Peripheral neuropathydiabetesmetformin therapyvitamin B-12 supplementationvitamin B-12 deficiencydosage correlationmetformin durationJournal ArticleIndiaDepartment of Pharmacology, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, IndiaDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, IndiaBharat School of Pharmacy, Mangalpally, Ibrahimpatnam Hyderabad, IndiaDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, IndiaDepartment of Bio Technology, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, IndiaDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, IndiaDepartment of Pharm. D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad, India