Misri, RachitaKharkar, VidyaDandale, AmeetPatel, VidulaMahajan, SunandaKhopkar, Uday2009-05-282009-05-282008-07-18Misri R, Kharkar V, Dandale A, Patel V, Mahajan S, Khopkar U. Multiple capillary hemangiomas: a distinctive lesion of multicentric Castleman's disease and POEMS syndrome. Indian Journal of Dermatology, Venereology and Leprology. 2008 Jul-Aug; 74(4): 364-6http://imsear.searo.who.int/handle/123456789/52603A diagnosed case of Castleman's disease, proven by biopsy from enlarged inguinal lymph nodes, presented with multiple, asymptomatic, erythematous papules and nodules prevalent since nine years over the trunk and extremities. The lesions had been gradually increasing in number and size. The patient had had plasmacytoma of the lower thoracic vertebra 12 years ago, for which he was adequately treated with chemotherapy and local radiotherapy. Dermatological examination revealed erythematous papules and nodules on the face, trunk, and extremities that were diagnostic of capillary hemangiomas. Histopathology of the erythematous, soft papule was suggestive of capillary hemangioma. Contrast-enhanced computerized tomography of the abdomen and pelvis showed multiple retroperitoneal nodes suggestive of Castleman's disease along with multiple osteolytic lesions in the pelvic girdle and vertebrae. The patient was treated with injection rituximab and is currently under follow-up. We report this case to highlight a rare association between Castleman's disease and POEMS syndrome.engAntibodies, Monoclonal --therapeutic useGiant Lymph Node Hyperplasia --complicationsHemangioma, Capillary --etiologyHumansImmunologic Factors --therapeutic useMaleMiddle AgedNeoplasms, Multiple Primary --etiologyPOEMS Syndrome --complicationsSkin Neoplasms --etiologyCase Reports