Biradar, SandeepVeeresh, B2013-07-302013-07-302013-03Biradar Sandeep, Veeresh B. Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats. Indian Journal of Experimental Biology. 2013 Mar; 51(3): 256-261.http://imsear.searo.who.int/handle/123456789/147590The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.enAcute pancreatitisAnti-inflammatoryCytokinesL-arginineLawsoneAcute DiseaseAnimalsAnti-Inflammatory Agents --pharmacologyAnti-Inflammatory Agents --therapeutic useAntioxidants --metabolismArginine --adverse effectsC-Reactive Protein --metabolismCytokines --metabolismEnzyme Inhibitors --pharmacologyInterleukin-6 --metabolismInterleukins --metabolismMaleNaphthoquinones --pharmacologyNeutrophils --metabolismOxidative StressPancreas --metabolismPancreatitis --chemically inducedRatsRats, WistarThiobarbituric Acid Reactive Substances --metabolismTumor Necrosis Factor-alpha --metabolismArticle