Devi, Sandhya GGoyal, ManuRamakrishna, N V S SMurthy, S Sudha2012-10-082012-10-082011-01Devi Sandhya G, Goyal Manu, Ramakrishna N V S S, Murthy S Sudha. CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern. Indian Journal of Pathology & Microbiology. 2011 Jan-Mar 54(1): 176-179.http://imsear.searo.who.int/handle/123456789/141949Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocations the usual FISH signal pattern is 1 red-1 yellow fusion signal pattern We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocations t(4;11) (q21;q23),however,with an unusual MLL FISH signal pattern.enB lymphoblastic leukemiaCALLA negativeconventional karyotypingfluorescent in-situ hybridizationmixed lineage leukemia geneHumansIn Situ Hybridization, Fluorescence --methodsInfantMaleMyeloid-Lymphoid Leukemia Protein --geneticsPrecursor B-Cell Lymphoblastic Leukemia-Lymphoma --diagnosisPrecursor B-Cell Lymphoblastic Leukemia-Lymphoma --pathologyTranslocation, GeneticArticle