K, SV, MB, SM, T.2023-07-142023-07-142022-01K S, V M, B S, M T.. A Prospective Randomised Study Comparing Neuromuscular Blockade And Recovery Characteristics Of Two Different Doses Of Cis - Atracurium Versus Atracurium In Elective Surgeries . National Journal of Integrated Research in Medicine. 2022 Jan; 12(6): 26-310975-98402230 - 9969http://imsear.searo.who.int/handle/123456789/219822Background:Cisatracurium is the stereoisomer of atracurium but has considerably higher neuromuscular blocking potency, better hemodynamic profile and no association with dose-dependent histamine release, as compared with the parent compound(1)(2,3). On the other hand, 2 ED95dose s of cis-atracurium (100? g/kg) do not create satisfactory intubating conditions such as those seen with equipotent doses of atracurium.There are limited studies which provide us the clarity of a better neuromuscular blocker in terms of intubation and maintainence amongst the two with the most optimum dose. Material And Methods:The study designed as randomised controlled trial, recruited 150 patients into three groups: Group A-atracurium 0.5 mg/kg(2×ED95), Group B and C-cis-atracurium 0.2 mg/kg (4×ED95) and 0.4 mg/kg (8×ED95)respectively and compared them on the basis of onset, duration of action, recovery time, haemodynamic effect and signs of histamine release clinically. Result:Patients in Group C had significantly shorter onset time of block when c ompared with group A & B. Mean duration of block after loading dose was significantly shorter in Group A than group B & C. Group B had a shorter duration of block than C. Recovery time of block in group A was significantly shorter than group B & C. Conclusion:Cis-atracurium in dose of 0.2 mg/kg seems to be better alternative to atracurium 0.5 mg/kg and cis-atracurium 0.4 mg/kg in providing faster onset, intermediate duration of action with fast recovery and it can be used for intubation as well as maintenance.Endotracheal intubationAtracuriumCis-atracuriumJournal ArticleIndiaSenior Resident, Department Of Anaesthesiology, SMS Medical College, Jaipur, 302004, IndiaPost Graduate, Department Of Anaesthesiology And Critical Care, Dr. S.N. Medical College, Jodhpur, 342003, IndiaSenior Resident, Department Of General Surgery, J.N.U. Institute For Medical Sciences And Research Centre, Jaipur, 302017, IndiaSenior Resident, Department Of Anaesthesiology, R.U.H.S College Of Medical Sciences, Jaipur, 302033, India