Sharma, KKhosla, P KTiwari, H KSharma, R KBajaj, J S1991-10-012009-05-291991-10-012009-05-291991-10-01Sharma K, Khosla PK, Tiwari HK, Sharma RK, Bajaj JS. Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes. Indian Journal of Ophthalmology. 1991 Oct-Dec; 39(4): 174-5http://imsear.searo.who.int/handle/123456789/70273Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy. Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported.engDiabetes Mellitus, Type 1 --bloodDiabetic Retinopathy --bloodHLA-B Antigens --bloodHistocompatibility TestingHumansInsulin Antibodies --bloodRadioimmunoassayComparative Study