Mahmoud, S. M.Kassab, R. B.Moneim, A. E. A.2020-09-242020-09-242020-01Mahmoud S. M., Kassab R. B., Moneim A. E. A.. Zinc Oxide Nanoparticles Ameliorate Aluminum Chloride-Induced Hepato-Renal Oxidative Stress And Inflammation In Rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Jan; 12(1): 11-200975-14912656-0097http://imsear.searo.who.int/handle/123456789/206053Objective: The present study was designed to evaluate the effect of zinc oxide nanoparticles (ZnO NPs) on Aluminum chloride (AlCl3)-induced hepato-renal injury.  Methods: Animals were divided into, I-control group; rats received saline, II-AlCl3 group; animals received 100 mg AlCl3/kg body weight, III-ZnO NPs group; rats received 10 mg ZnO NPs/kg body weight, and IV group ZnO NPs+AlCl3. All rats were administered their respective doses daily for 6 w. Hepatorenal function parameters in sera; aminotransferases, bilirubin, urea, and creatinine were estimated. Lipid peroxide level and nitrite\nitrate ratio, glutathione content, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase activities and interleukin-1β, tumor necrosis factor-α levels were determined in both tissues. The histopathological and the immunohistochemical investigations of nuclear factor-kB expression were carried out.  Results: ZnO NPs treatment to AlCl3-intoxicated rats significantly reduced Al accumulation (at p<0.05) in the hepatorenal tissue and increased zinc accumulation (at p<0.05) in liver and kidney, respectively, with respect to AlCl3-group, thus inhibiting oxidative stress and inflammation parameters represented by lipid peroxidation and nitric oxide levels (at p<0.05) compared to AlCl3 group and elevated antioxidant parameters (at p<0.05), compared to AlCl3 treated group, while suppressed interleukin-1β, tumor necrosis factor-α levels (at p<0.05) and the nuclear factor-kB activation in liver and kidney, especially in the kidney if compared to AlCl3-treated group. Hepatorenal function indices indicated significant decreases compared to AlCl3 group (at p<0.05). Conclusion: Results indicated the ameliorative effect of ZnO NPs on aluminum-induced hepato-renal damage.Zinc nanoparticlesAluminumInflammationOxidative stressLiverKidneyJournal ArticleIndiaAssistant Professor of Physiology at Department of Zoology, Faculty of Science, Cairo University, Cairo, EgyptAssistant Professor of Physiology at Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, EgyptProfessor of Physiology at Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt