Tirpude, Rakhee MGajbhiye, Ipr2016-02-082016-02-082011-07Tirpude Rakhee M, Gajbhiye Ipr. Simple Reaction Time: Simple Measure To Quantify Quality of Life of Epileptics. JK Science Journal of Medical Education and Research. 2011 Jul-Sept;13(3): 135-140http://imsear.searo.who.int/handle/123456789/172075The most activities of CNS are initiated by sensory experience emanating from receptions from eyes and ears and causes immediate reaction from brain. In epileptic patient, neuronal metabolic disturbances produces prolonged depolarization and require antiepileptic drugs to stabilized seizure which decreases responsiveness of neurons to excitation and doesn't necessarily correct the specific etiology of seizure. Considering all these factors, there is need to measure quality of life in patients in order to optimize the outcome by more appropriate intervention, hence simple reaction time (RT) studies for Red, Green, Indigo colors and high and low frequency auditory stimuli was carried out on 40 epileptic subjects (F-20& M -20) and compare with age and sex matched controlled. RTs were found to be delayed in female but failed to reach significance. (Red=173.85±27.63, Green = 175±26.22, Indigo=174.25±24.58, High=171.20±23.63, Low= 177.60±26.13). In males RT for red color was highly significant and rest of parameters was insignificant. (Red=196.40±41.72 {p-0.06}, green=193.45±52.72 Indigo=192.40±40.19, high=187.90±22.45, low= 201.00 ±50.64). The RTs were insignificantly shortened in female epileptic when compared with male epileptics. Also we found significant rise in male epileptics taking polytherepy. The reaction time shows insignificant effect on prolonged use of drugs but that has to be verified with further studies. In concluding, unpleasant effects of drugs can be reduced with meticulous selection and proper dose of AED. This study also suggests reaction analyzer as a better non invasive alternative tool for regular evaluation of hypo reflexes in epileptic patients.enReaction timeAntiepileptic DrugsEpilepsyPolytherepyArticle