Kumar, A K HemanthGurumurthy, Prema2009-05-282009-05-282004-03-06Kumar AK, Gurumurthy P. Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs. Indian Journal of Experimental Biology. 2004 Mar; 42(3): 323-5http://imsear.searo.who.int/handle/123456789/62816Disposition of uric acid upon administration of ofloxacin (O) alone and in combination with other anti-tuberculosis drugs, rifampicin (R), isoniazid (H) and pyrazinamide (Z) was studied. Twelve male healthy volunteers were investigated on four different occasions with the four drugs alone or in combinations. A partially balanced incomplete block design was adopted and the subjects were randomly allocated to each group. Uric acid concentration in urine samples excreted over 0-8 hr, were determined after coding the samples. There was significant decrease in the group receiving Z when compared to other groups. Though there was a decrease in uric acid excretion in the group receiving O, it was not statistically significant. Rifampicin and H seem to increase the uric acid excretion. The incidence of arthralgia was mainly due to Z and not due to either O or other drugs in the treatment of pulmonary tuberculosis.engAdultAntitubercular Agents --administration & dosageClinical Trials as TopicHumansIsoniazid --administration & dosageMaleOfloxacin --administration & dosagePyrazinamide --administration & dosageRifampin --administration & dosageUric Acid --urineClinical Trial