Kaushal, VChhina, D KKumar, RPannu, H SDhooria, H P SChhina, R S2008-04-012009-05-282008-04-012009-05-282008-04-01Kaushal V, Chhina DK, Kumar R, Pannu HS, Dhooria HP, Chhina RS. Acanthamoeba encephalitis. Indian Journal of Medical Microbiology. 2008 Apr-Jun; 26(2): 182-4http://imsear.searo.who.int/handle/123456789/54137Central nervous system infection with free-living amoebae is rare. We present a fatal case of Acanthamoeba encephalitis in a 63-year-old female from India where acanthamoebae were demonstrated and cultured from CSF. In spite of treatment with amphotericin B, fluconazole and rifampicin the patient did not survive. Amoebic infection should be suspected in a patient of encephalitis of unexplained aetiology as timely diagnosis can lead to a favourable outcome.engAcanthamoeba --isolation & purificationAmebiasis --diagnosisAmphotericin B --therapeutic useAnimalsAnti-Bacterial Agents --therapeutic useAntifungal Agents --therapeutic useCerebrospinal Fluid --parasitologyEncephalitis --parasitologyFatal OutcomeFemaleFluconazole --therapeutic useHumansIndiaMiddle AgedRifampin --therapeutic useCase Reports