Assanasen, ThamathornWannakrairot, PongsakKeelawat, SomboonRuangvejvorachai, PreechaPramprayoon, Nootchanat2009-05-272009-05-272005-09-21Assanasen T, Wannakrairot P, Keelawat S, Ruangvejvorachai P, Pramprayoon N. Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital. Journal of the Medical Association of Thailand. 2005 Sep; 88 Suppl 4(): S266-73http://imsear.searo.who.int/handle/123456789/39664Chotmaihet Thangphaet.BACKGROUND: High frequency of Epstein-Barr virus (EBV) in the normal mucosa of the upper aerodigestive tract suggests that it may serve as a reservoir for the virus. Malignant lymphomas arising in this site may be associated with EBV. OBJECTIVES: To determine the prevalence of EBV infection in extranodal malignant lymphomas of the upper aerodigestive tract. SETTING: King Chulalongkorn Memorial Hospital, Thailand. DESIGN: Descriptive study. PATIENTS: 42 Thai patients who presented between 1998 and 2003. MATERIAL AND METHOD: The expression of EBV mRNAs (EBERs) of malignant lymphoma was studied by means of in situ hybridization in formalin-fixed, paraffin-embedded specimens. RESULTS: The recruited subjects were 26 males and 16 females, and their age ranged from 3 to 85 years with the mean of 51.43 years, in 4 of them human immune deficiency virus (HIV) infection was documented. Ten of 42 cases (23.81%) expressed EBER transcripts and were extranodal NK/T-cell lymphomas, nasal type (7 cases), plasmablastic lymphomas (2 cases) and diffuse large B-cell lymphoma (1 case). Three of 4 cases (75%) of known HIV-seropositive cases were EBV-positive (2 plasmablastic lymphomas and 1 diffuse large B-cell lymphoma). CONCLUSION: In the upper aerodigestive tract, EBV was present in some but not all malignant lymphoma. It was associated with extranodal NK/T-cell lymphoma, nasal type and B-cell lymphoma arising in HIV-infected patients, but it was not found in B-cell lymphoma arising in immunocompetent patients.engAdolescentAdultAgedAged, 80 and overChildChild, PreschoolDisease ReservoirsEpstein-Barr Virus Infections --epidemiologyFemaleHerpesvirus 4, Human --isolation & purificationHumansIn Situ HybridizationLymphoma --physiopathologyLymphoma, B-Cell --physiopathologyLymphoma, T-Cell --physiopathologyMaleMiddle AgedPrevalenceRespiratory System --physiopathologyRisk FactorsThailand --epidemiologyUpper Gastrointestinal Tract --physiopathologyJournal Article