Kalsotra, ParmodKumar, SGosh, PMishra, N KVerma, I C2016-01-252016-01-252002-07Kalsotra Parmod, Kumar S, Gosh P, Mishra N K, Verma I C. A Study of Congenital and Early Acquired Impairment of Hearing. JK Science Journal of Medical Education and Research. 2002 Jul-Sept.4 (3): 138-143http://imsear.searo.who.int/handle/123456789/170919The present study included 261 patients (M:F=I.72: I) suffering from congenital and early acquired hearing loss. The aetiological breakup of the hearing loss was: genetic factors 47.5%. non-genetic factors 16.8%, congenital ear malfonnations 8.5% and cryptogenic factors in 27.2% cases. Autosomal recessive mode of inheritance was seen most commonly (62%) followed by autosomal dominant (20%) in the genetic group of hearing loss. Maternal Rubella was most common cause of prenatal group of hearing loss while perinataly birth anoxia and prematurity were common. Postnataly meningitis was most common aetiology ofhearing loss. Linkage analysis on SLINK 2 point autosomal data yielded LOD score of more than 3 in an autosomal dominant family.enCongenitalGeneticNon-geneticHearing lossArticle