Punkae Mahaisavariya2011-02-242011-02-242010-05-082010-05-08Srinagarind Medical Journal (SMJ); Vo. 3 No. 1 January - March 1988; 45-50http://imsear.searo.who.int/handle/123456789/133765 Systemic sclerosis is a widespread disturbance of connective tissue that involve the skin and various organs including the heart, lungs kidneys and gastrointestinal tract. Pathogenesis and therapeutic options of this disease are described in detailen-USAcademic Affairs, Faculty of Medicine, Khon Kaen University, KhonKaen, ThailandReview Articles