Khanam, RaziaPillai, K K2009-05-282009-05-282006-02-17Khanam R, Pillai KK. Involvement of potassium channels in hypoglycemic effect of sertraline. Indian Journal of Experimental Biology. 2006 Feb; 44(2): 120-2http://imsear.searo.who.int/handle/123456789/58901Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.engAnimalsDiabetes Mellitus, Experimental --chemically inducedDose-Response Relationship, DrugGlucose --analysisHyperglycemia --chemically inducedHypoglycemic Agents --pharmacologyMuscle Relaxation --drug effectsPinacidil --pharmacologyPotassium Channels --physiologyRatsRats, WistarSertraline --pharmacologyStreptozocinSulfonylurea Compounds --pharmacologyVasodilation --drug effectsVasodilator Agents --pharmacologyJournal Article