Dwipayana, Putu AdityaSuryana, Ketut2023-08-282023-08-282022-12Dwipayana Putu Aditya, Suryana Ketut. Safety of oral graded challenges as a diagnostic approach hypersensitivity reaction to anti-tuberculosis drugs: a case report. International Journal of Advances in Medicine. 2022 Dec; 9(12): 1203-12062349-39332349-3925http://imsear.searo.who.int/handle/123456789/225931Tuberculosis (TB) still becomes a significant health problem in developing countries, especially in Indonesia. Allergy to antitubercular drugs is a real hindrance to the management of TB. The first-line anti-TB drug (ATD) is still the most effective TB drug, but it can have some side effects. One of these side effects is drug hypersensitivity reactions (DHR) which can affect a patient's compliance. The recommended diagnostic approach to DHR is a graded challenge by introducing drugs safely and optimally under a threshold dose until the usual daily dose is reached. We present a case of DHR to ATB drug and oral graded challenge as the diagnosis approach.Graded challengesSafetyDHRJournal ArticleIndiaDepartment of Internal Medicine, Wangaya General Hospital, Denpasar, Bali, IndonesiaDepartment of Internal Medicine, Merpati Clinic HIV, Allergy-Clinical Immunology Services Unit, Wangaya General Hospital, Denpasar, Bali, Indonesia