Dadhich, A PKhanna, N KVyas, D SJain, P1979-01-012009-06-011979-01-012009-06-011979-01-01Dadhich AP, Khanna NK, Vyas DS, Jain P. Neuropharmacological actions of labetalol. Indian Journal of Physiology and Pharmacology. 1979 Jan-Mar; 23(1): 39-43http://imsear.searo.who.int/handle/123456789/107298Labetalol, an alpha- and beta- adrenoceptor antagonist was investigated for its central nervous system effects in rats and mice. A marked reduction in the spontaneous motor activity with no concomittant muscle weakness was produced. The drug caused closure of eyelids in rats. Labetalol caused hypothermia and prolonged the pentobarbitone-induced hyposis. In animals trained for conditioned avoidance response the drug blocked the SCR in all the animals and CAR in a few number of animals. The drug did not protect the animals against electroshock convulsions. From the results it appears that labetalol is a central nervous system depressant.engAnimalsAvoidance Learning --drug effectsBody Temperature --drug effectsCentral Nervous System --drug effectsConditioning, Operant --drug effectsDepression, ChemicalDrug SynergismEthanolamines --pharmacologyFemaleHypnotics and Sedatives --pharmacologyLabetalol --pharmacologyMaleMiceMotor Activity --drug effectsPentobarbital --pharmacologyRatsSeizures --prevention & controlJournal Article