Mohta, MedhaKumar, VijayAgarwal, RachnaChilkoti, Geetanjali T.Duggal, Sakshi2020-01-022020-01-022019-01Mohta Medha, Kumar Vijay, Agarwal Rachna, Chilkoti Geetanjali T., Duggal Sakshi. Efficacy of Phenylephrine in Preventing Hemodynamic Responses of Oxytocin during Elective Cesarean Section:A Randomized,Double-Blind ,Controlled Trial . Annals of the National Academy of Medical Sciences (India). 2019 Jan; 55(1): 48-530379-038Xhttp://imsear.searo.who.int/handle/123456789/189735This study compared hemodynamic changes and occurrence of complications following oxytocin administration with a prior injection of phenylephrine 100 μg or normal saline during elective cesarean section. Sixty-six healthy term parturients with uncomplicated, singleton pregnancy undergoing elective cesarean section under spinal anesthesia were studied. They received either intravenous phenylephrine 100 μg or normal saline before oxytocin 3 IU was administered over 30 seconds. Oxytocin dose was repeated depending on the adequacy of uterine tone. There was no significant change in systolic, diastolic, and mean arterial pressures during the initial 3 minutes following oxytocin administration in the phenylephrine group but a significant fall in mean and diastolic pressures in the saline group. Heart rate did not change significantly, and no significant complications occurred in either of the groups. To conclude, phenylephrine 100 µg administered before oxytocin injection maintained hemodynamic parameters better than normal saline injection during elective cesarean sectionJournal ArticleIndiaDepartment of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, IndiaDepartment of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, IndiaMBBS, MD, MAMS, 28-B, Pocket-C, SFS Flats, Mayur Vihar Phase-III, Delhi 110096, India, medhamohta@gmail.com