Taghi, AziziMotamedi, Mohammad Hosein Kalantar2012-07-202012-07-202009-04Taghi Azizi, Motamedi Mohammad Hosein Kalantar. Riga-Fede disease: A histological study and case report. Indian Journal of Dental Research. 2009 Apr-Jun; 20(2): 227-229.http://imsear.searo.who.int/handle/123456789/139718Acute traumatic ulcerations and granulomas of the oral mucosa may result from physical damage via sharp foodstuffs, accidental biting, or talking. Most ulcerations heal within days. Others become chronic, reactive, and exophytic. A histopathologically unique type of chronic traumatic ulceration is the traumatic ulcerative granuloma with stromal eosinophilia (TUGSE). TUGSE exhibits a deep "pseudoinvasive" inflammatory reaction. This lesion may occur under the tongue in infants as a result of chronic mucosal trauma caused by mandibular anterior primary teeth during nursing and is termed Riga-Fede disease (RFD). The clinical presentation many resemble squamous cell carcinoma causing concern. RFD, although not uncommon, is not frequently reported. Thus, dental practitioners are unfamiliar with such lesions. We present a large Riga-Fede lesion in an infant along with the clinical management.enRiga-Fede diseasetraumatic granulomaulcerative granulomaChronic DiseaseDiagnosis, DifferentialGranuloma --pathologyHumansInfantMaleOral Ulcer --diagnosisOral Ulcer --pathologyTongue --injuriesTongue Diseases --diagnosisTongue Diseases --pathologyTooth EruptionArticle