Chandrasekaran, ShanmugapriyaGopinath, Poonguzhali2019-12-022019-12-022019Chandrasekaran Shanmugapriya, Gopinath Poonguzhali. TCF7L2 gene variant rs7903146 affects the risk of Type 2 Diabetes by modulating incretin secretion. International Archives of Integrated Medicine. 2019 Mar; 6(3): 95-982394-00262394-0034http://imsear.searo.who.int/handle/123456789/187261Background: Type2 diabetes mellitus (T2DM) is a highly inheritable disease. Transcription factor 7- like 2 (TCF7L2) gene regulates the expression of glucagon-like peptide 1 (GLP-1) in L cells of small intestine. GLP1 plays a critical role in blood glucose homeostasis by stimulating postprandial insulin secretion and increasing insulin sensitivity. Aim of the study: TCF7L2 gene variants may affect the susceptibility to Type 2 diabetes by altering GLP-1 levels. Materials and methods: This case-control study was conducted with 90 newly diagnosed patients with Type2 diabetes mellitus as cases and 90 age and sex-matched healthy volunteers as controls. TCF7L2 rs7903146 genotyping was done and we also estimated Fasting and postprandial GLP -1 level, Fasting and Postprandial insulin level and calculated HOMA-IR in both cases and controls. Results: Out study showed that T+ genotype, lower fasting GLP-1 level and lower postprandial GLP1 levels were more observed among cases as compared to controls. Low mean GLP 1 activity, high Mean HOMA-IR, low postprandial insulin, low percentage rise in insulin were observed among T+ genotype than among T- genotypic individuals. Conclusion: Hence, the study concludes that T+ genotype causes a decrease in GLP-1 levels, which in turn by decreasing postprandial insulin levels and by increasing insulin resistance increases the risk of Type2 diabetes.GliptinsGLP-1IncretinsPolymorphismType 2 diabetesTCF7L2rs7903146Journal ArticleIndiaAssociate Professor, Department of Biochemistry, Government Medical College, Omandurar Govt. Estate, Chennai, Tamil Nadu, IndiaAssociate Professor, Department of Biochemistry, Government Villupuram Medical College and Hospital, Villupuram, Tamil Nadu, India, poonguzhalig@gmail.com