Desai, D CWagle, S DMohandas, K MSwaroop, V S1997-01-012009-05-291997-01-012009-05-291997-01-01Desai DC, Wagle SD, Mohandas KM, Swaroop VS. Dilatation of radiation-induced esophageal strictures under sublingual buprenorphine analgesia: a pilot study. Indian Journal of Gastroenterology. 1997 Jan; 16(1): 14-5http://imsear.searo.who.int/handle/123456789/65420BACKGROUND: Pain during dilatation of radiation strictures is a troublesome complaint. There is little information on sedation and analgesia during this procedure. We performed a pilot study to compare the analgesic efficacy of sublingual buprenorphine and intravenous pentazocine during dilatation of radiation-induced esophageal strictures. METHODS: Thirty-one patients with esophageal cancer who had radiation-induced strictures were randomized to receive either buprenorphine 0.2 mg sublingually two hours before dilatation (n = 17) or pentazocine 30 mg intravenously five minutes before dilatation (n = 14). Dilatation was considered successful if it could be performed to 12 mm diameter or more. Pain experienced during dilatation was graded as mild, moderate or severe. RESULTS: Sixteen patients in the buprenorphine group and 12 in the pentazocine group were dilated to > 12 mm size (p = ns). Twelve and nine patients respectively in the two groups experienced mild or no pain; ten and six patients had minor side-effects (p = ns). CONCLUSION: Buprenorphine is useful for sedoanalgesia during dilatation of radiation-induced strictures of the esophagus.engAdministration, SublingualAdultAgedAnalgesics, Opioid --administration & dosageAnesthesia, Local --methodsBalloon Dilatation --methodsBuprenorphine --administration & dosageEsophageal Neoplasms --radiotherapyEsophageal Stenosis --etiologyFemaleHumansInjections, IntravenousMaleMiddle AgedPentazocine --administration & dosagePilot ProjectsProspective StudiesRadiation Injuries --complicationsTreatment OutcomeClinical Trial