Gupta, NidhiGupta, RituSharawat, Surender KumarBakhshi, Sameer2015-03-242015-03-242010-10Gupta Nidhi, Gupta Ritu, Sharawat Surender Kumar, Bakhshi Sameer. Childhood Chronic Myeloid Leukemia with Monocytosis. Indian Journal of Pediatrics. 2010 Oct; 77 (10): 1143-1146.http://imsear.searo.who.int/handle/123456789/157153We report two cases of chronic myeloid leukemia (CML) in childhood presenting with monocytosis. History, physical examination and laboratory findings were in favor of juvenile myelomonocytic leukemia in both the cases, but reverse transcriptase polymerase chain reaction (RT-PCR) detected b2a2 and b3a2 transcript of p210 bcr-abl protein characteristic of major BCR breakpoint. Presence of monocytosis in early childhood suggests a viral infection or JMML but a possibility of CML with monocytosis needs to be considered.enCMLMonocytosisMajor BCR breakpointArticle