Parakh, NupurKhan, AfreenSharma, SunitaChandra, Jagdish2023-08-252023-08-252023-08Parakh Nupur, Khan Afreen, Sharma Sunita, Chandra Jagdish. Clinico-Hematological Profile and Management of Children With Non-Transfusion Dependent Thalassemia (NTDT) at a Pediatric Center in Northern India. Indian Pediatrics. 2023 Aug; 60(8): 644-6470079-60610974-7559http://imsear.searo.who.int/handle/123456789/225450Objective: To study the clinico-hematological profile, complications, and management of children with non-transfusion dependent thalassemia (NTDT) in northern India. Method: We retrieved and analyzed the data of 69 children with NTDT diagnosed between January, 2006 to December, 2018, aged under 18 years from our unit’s records. Result: The participants mean (SD) age was 4.4 (3.1) years, and they presented with anemia (29%), jaundice (13%), hemolytic facies (13%), splenomegaly (87%), thromboembolism (2.9%) and pathological short stature (28.5%). The most common cause of NTDT was ?-thalassemia (45%), followed by either compound-heterozygous or homozygous for E?-thalassemia mutation. The most frequent single genotype observed was compound heterozygous for IVS1-5 (G>C) and codon 26 (G>A). The mean (SD) follow-up duration was 3.5 (2.4) years. On follow-up, 27 children (%) remained transfusion free, and 30 (%) needed occasional transfusions. 63% of patients initially presenting with pathological short stature showed improvement in growth. Amongst children older than 10 years (n=20), subclinical hypothyroidism was detected in 6 children and impaired glucose tolerance test in 1 child. Conclusion: Eß-thalassemia was the commonest cause of NTDT in this population.ChelationIron overloadThrombosis.Journal ArticleIndiaDepartment of Pediatrics, Kalawati Saran Children’s Hospital, New DelhiDepartment of Pediatrics, Hamdard Institute of Medical Sciences and Research Institute, New DelhiDepartment of Pathology, Kalawati Saran Children’s Hospital, New Delhi.