Hebbar, Sahana K.P., DeepakG. K., NaliniC. V., KavithaG. N., SahanaNagaral, Jayashree V.2020-04-232020-04-232019-02Hebbar Sahana K., P. Deepak, G. K. Nalini, C. V. Kavitha, G. N. Sahana, Nagaral Jayashree V.. A prospective evaluation of efficacy and safety of topical bromfenac 0.09% over topical flurbiprofen 0.03% after cataract surgery. International Journal of Basic & Clinical Pharmacology. 2019 Feb; 8(2): 234-2392319-20032279-0780http://imsear.searo.who.int/handle/123456789/200004Background: Different medications are used to reduce pain and inflammation after cataract surgery. Hence this study was taken up to compare the efficacy and safety of topical bromfenac 0.09% over topical flurbiprofen 0.03% in reducing anterior chamber inflammation and pain after cataract surgery.Methods: Total of 100 patients who underwent uneventful cataract surgery with posterior chamber intra ocular lens (IOL) implantation were randomly allocated to receive bromfenac 0.09% and flurbiprofen 0.03% topically from first post-operative day onwards for 6 weeks. Assessment of anterior chamber inflammation and pain was done by slit lamp and visual analogue scale respectively on each follow up days. Analysis was done by unpaired t test and Fischer’s exact test.Results: The response to treatment was earlier in bromfenac group for all the inflammatory changes (significant difference was found on day 7, p<0.05) except for corneal edema where both the groups showed similar response. On 7th day after surgery, 72% patients in flurbiprofen group and 12% in bromfenac group had pain (score1), while on the 14th day none in the bromfenac group complained of pain whereas 4% in flurbiprofen group still had pain. Both the drugs were safe and no clinically serious adverse effects were observed in either of the groups.Conclusions: This study showed both the medications, topical bromfenac 0.09% and topical flurbiprofen 0.03% effective and safe in reducing pain and anterior chamber inflammation after cataract surgery but the response was earlier with bromfenac 0.09%.Anterior chamber inflammationBromfenacFlurbiprofenPost-operative painProstaglandinsJournal ArticleIndiaDepartment of Pharmacology, HIMS, Hassan, Karnataka, IndiaDepartment of Ophthalmology, HIMS, Hassan, Karnataka, India