Sethi, O PGupta, M VBhatia, O SDerasari, H R1977-01-012009-06-011977-01-012009-06-011977-01-01Sethi OP, Gupta MV, Bhatia OS, Derasari HR. Sedative action of some substituted benzylamides. Indian Journal of Physiology and Pharmacology. 1977 Jan-Mar; 21(1): 1-10http://imsear.searo.who.int/handle/123456789/108557Substituted benzylamide derivatives of amino acylamide (compound A,B,C, & D) were found to be less potent local anaesthetics than lignocaine and procaine. However, the four compounds exhibited sedation without ptosis and reduced spontaneous locomotor activity better than methaqualone. Compound A alone antagonised methylamphetamine induced hypermotor activity. The test compounds potentiated hexobarbitone induced hypnosis. Three compounds antagonised calcium induced stoppage of isolated heart of frog. Except compound C all caused a transitory fall of blood pressure in dog which was not blocked either by atropine or propranolol. These compounds showed neuromuscular blockade and possessed slight analgesic activity but were devoid of anticonvulsant and tranquillizing activity. LD 50 values were calculated to be 164.1 +/- 23.0, 229.1 +/- 51.0, 181.6 +/- 28.18 and 416+/-38.2 mg/kg for compounds A,B,C & D respectively.engAmides --pharmacologyAnesthetics, LocalAnimalsAnuraBenzyl Compounds --pharmacologyBlood Pressure --drug effectsDepression, ChemicalDogsFemaleGuinea PigsHeart --drug effectsHypnotics and SedativesIleum --drug effectsMaleMiceMotor Activity --drug effectsMuscle, Smooth --drug effectsMuscles --drug effectsRabbitsRatsIn Vitro