Tyagi, M GStephen, P M2009-05-282009-05-281990-10-01Tyagi MG, Stephen PM. Reversal of angiotensin converting enzyme (ACE) inhibitor induced vasodilatation by vasopressin in hindquarters of rat. Indian Journal of Experimental Biology. 1990 Oct; 28(10): 992-3http://imsear.searo.who.int/handle/123456789/55926The effect of exogenously administered vasopressin was observed on captopril induced vasodilatation in hindquarters of anaesthetised rats. Drops of perfusate were counted for 6 min and mean of the outflow was expressed as drops per min (dpm). In the control group (n = 6) the rate of flow was 9.5 +/- 1.04 dpm which increased to 12.33 +/- 1.36 dpm following captopril (200 micrograms/ml) infusion. In test group (n = 6) pretreated with vasopressin (4 I.U./kg 1 hr before) the rate of flow was 9.16 +/- 0.98 dpm which was reduced to 5.5 +/- 1.04 dpm following infusion with captopril. It is concluded that vasopressin reverses the vasodilatory effect of captopril.engAnimalsCaptopril --pharmacologyFemaleMaleRatsRats, Inbred StrainsVasodilation --drug effectsVasopressins --pharmacologyIn Vitro