Sharma, Ratti RamBhattacharya, PrasunThakral, BeenuSaluja, KaranMarwaha, Neelam2012-09-202012-09-202009-10Sharma Ratti Ram, Bhattacharya Prasun, Thakral Beenu, Saluja Karan, Marwaha Neelam. Transfusion related acute lung injury. Indian Journal of Pathology & Microbiology. 2009 Oct-Dec; 52(4): 561-563.http://imsear.searo.who.int/handle/123456789/141553Transfusion related acute lung injury (TRALI) is an uncommon but potentially fatal adverse reaction to transfusion of plasma containing blood components. We describe a case of 10-year-old male child with aplastic anemia, platelet count of 7800/΅l, B positive blood group who developed fever (39.2΀C), difficulty in breathing and cyanosis within 2 hrs after transfusion of a random platelet concentrate. Despite the best resuscitative efforts, the child died within next 24 hrs. The present case highlights the fact that TRALI should be kept as a differential diagnosis in all patients developing acute respiratory discomfort within 6 hrs of transfusion. Without a 'gold standard' the diagnosis of TRALI relies on a high index of suspicion and on excluding other types of transfusion reactions. Notification to transfusion services is crucial to ensure that a proper investigation is carried out and at-risk donor and recipients can be identified, and risk reduction measures can be adopted.enBlood componentslung injurytransfusionArticle