Zhu, S LYe, S TYu, Y2009-05-272009-05-271989-06-01Zhu SL, Ye ST, Yu Y. Allergenicity of orange juice and orange seeds: a clinical study. Asian Pacific Journal of Allergy and Immunology. 1989 Jun; 7(1): 5-8http://imsear.searo.who.int/handle/123456789/36673Published by the Allergy and Immunology Society of Thailand.Oranges are considered to be common allergenic fruits in China. They may induce severe food allergy in sensitive individuals. Allergic histories were analyzed in 26 orange-sensitive patients. Intradermal tests with extracts of orange juice and seeds were performed in 16 out of the 26 patients. P-K test was performed in one patient. The allergic history analysis suggested that clinical symptoms of some orange-allergic subjects were different from other fruit allergies but similar to nut and other oil plant seed allergies. The skin test and P-K test showed that the major allergenic components of orange reside in orange seeds instead of orange juice. Systemic reactions developed in 5 patients after intradermal tests with 1:20-200 (w/v) orange seed extracts. We considered that orange seed contains high potent allergens which may induce orange sensitivity due to careless chewing of orange seeds.engAdultAllergens --standardsBeverages --adverse effectsChinaCitrus --adverse effectsFemaleFood Hypersensitivity --immunologyHumansMaleMedical History TakingMiddle AgedSeeds --immunologySkin Tests --methodsJournal Article