Nagar, R NBhattacharya, L2001-01-022009-06-022001-01-022009-06-022001-01-02Nagar RN, Bhattacharya L. Effect of mercuric chloride on testicular activities in mice, Musculus albinus. Journal of Environmental Biology. 2001 Jan; 22(1): 15-8http://imsear.searo.who.int/handle/123456789/113609Impaired testicular function was observed after an exposure of Swiss albino mice (30 +/- 2 g) to mercuric chloride. A sublethal chronic exposure (0.5 ppm for 21 days) resulted in regressed histological and histochemical properties of the testis. The changes observed were degenerated tunica albuginea, abnormal configurations of seminiferous tubules, deformed primary and secondary spermatocytes, hypertrophy and vacuolization in interstitial cells and Sertoli cells. The 3 beta and 17 beta hydroxy steroid dehydrogenase enzyme and the level of testosterone hormone were significantly (p < 0.001) reduced. The diameter of different spermatogenic cells were significantly (p < 0.001) reduced.eng17-Hydroxysteroid Dehydrogenases --drug effects3-Hydroxysteroid Dehydrogenases --drug effectsAnimalsMaleMercuric Chloride --toxicityMiceSpermatogenesis --drug effectsTestis --cytologyTestosterone --bloodWater Pollutants --toxicityJournal Article