Aggarwal, SaritaSubberwal, ManjuKumar, SushilSharma, Meenakshi2006-01-142009-06-012006-01-142009-06-012006-01-14Aggarwal S, Subberwal M, Kumar S, Sharma M. Brain tumor and role of beta-carotene, a-tocopherol, superoxide dismutase and glutathione peroxidase. Journal of Cancer Research and Therapeutics. 2006 Jan-Mar; 2(1): 24-7http://imsear.searo.who.int/handle/123456789/111570The erythrocyte levels of the antioxidant enzymes SOD and GPx, and serum levels of antioxidants vitamins beta-carotene and beta-tocopherol were estimated in various types of brain tumors, and were compared with the levels in controls. Statistically significant (P<.001) diminished levels of beta-carotene, beta-tocopherol, SOD and GPx, were observed in all the brain tumor patients as compared to controls. Malignant tumor also showed a relative decrease in antioxidant levels as compared to benign tumors. Comparison of histopathological sections of brain tumors also suggested a inverse relationship between antioxidant level and grades of malignancy. Marked decrease in antioxidant levels may have a role in genesis of considerable oxidative stress in brain tumors. Furthermore, the degree of decline in antioxidant levels may indicate severity of malignancy in brain tumors.engAdolescentAdultAgedAntioxidants --analysisBrain Chemistry --physiologyBrain Neoplasms --bloodChildFemaleGlutathione Peroxidase --bloodHumansMaleMiddle AgedOxidative Stress --physiologySuperoxide Dismutase --bloodalpha-Tocopherol --bloodbeta Carotene --bloodJournal Article