Fetih, Ahmed N.Abbas, Ahmed M.Kamel, Fatma A.El Nashar, Ihab H.2020-10-162020-10-162019-11Fetih Ahmed N., Abbas Ahmed M., Kamel Fatma A., El Nashar Ihab H.. Tamoxifen for treatment of abnormal uterine bleeding in etonorgstrel implant users: a randomized clinical trial. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Nov; 8(11): 4462-44672320-17702320-1789http://imsear.searo.who.int/handle/123456789/207178Background: The current study aims to compare the use of tamoxifen and oral contraceptive pills in women using implanon and complain with irregular uterine bleeding.Methods: Women attended family planning clinic using implanon presented by bleeding were invited to participate in the study. They were randomized into two groups: Group A: 100 women received Tamoxifen 10 mg twice daily for 10 days taken at the onset of an episode of bleeding or spotting episode. Group B: 100 women received Combined oral contraceptive pills (microcept) once daily for 21 days take at the onset of an episode of bleeding or spotting episode.Results: No difference regarding the baseline criteria of both groups. No difference between both groups regarding the duration of irregular bleeding in the implanon users (p=0.090). Additionally, the number of bleeding days and spotting in the last month was similar in both groups (p=0.554). The percentage of women who stopped bleeding during the period of treatment is 84% in the tamoxifen group and 92% in the COCs group, but the COCs needs longer treatment time, where the mean of days required to stop bleeding is 5.03±1.8 days in the tamoxifen group and 6.5±2.5 in the COCs group. Headache and nausea were the most prominent adverse effects found in the COCs group (p=0.000).Conclusions: Oral administration of tamoxifen 10 mg twice daily for 10 days is effective on stopping bleeding attacks in implanon users.Abnormal uterine bleedingContraceptionFamily planningImplantsOral contraceptivesTamoxifenJournal ArticleIndiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Obstetrics and Gynecology, Dairout Central Hospital, Assiut, Egypt