Jidapa Thammasiri2011-02-222011-02-222010-04-062010-04-06Thai Cancer Journal; Vol.28 No.1 January-March 2008; 44-47http://imsear.searo.who.int/handle/123456789/132388This descriptive study was designed to study the histopathologic correlation of atypical squamous cell in cervical smear at the National Cancer Institute from October 1,2005 to September 30,2007. Sixty-three cases of ASC-US were performed colposcopic biopsy and/or LEEP. The histologic diagnosis revealed low grade lesion or LSIL in 11 cases (17.4%), high grade lesion (HSIL or worse) 16 cases (25.4%), atypical squamous metaplasia 1 case (1.6%), and inflammation 35 cases (55.6%). In the category of ASC-H, 105 cases were performed colposcopy, which the histologic diagnosis revealed low grade lesion or CIN 1 in 21 cases (20 %), high grade lesion (CIN 2 or worse) 45 cases (42.9%), atypical squamous metaplasia 7 cases (6.7 %), and inflammation 32 cases (30.5 %). Cases classified as ASC-H are associated with a significant risk of high grade lesion than ASC-US category. However, this study assumed that patients with atypical squamous cell either ASC-US or ASC-H according to the 2001 Bethesda System classification should receive the proper management since they have an increase risk of underlying cervical intraepithelial neoplasia and rarely carcinoma.en-USNational Cancer Institute of Thailand, Bangkok, ThailandResearch Articles