Gupta, S KGupta, RavikantYadav, Sanjay KumarKar, MousumiJain, D K2013-11-152013-11-152013-10Gupta S K, Gupta Ravikant, Yadav Sanjay Kumar, Kar Mousumi, Jain D K. Design and development of transdermal drug delivery system. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Oct-Nov; 2(6): 667-673.http://imsear.searo.who.int/handle/123456789/149350In the course of development of microspheres preparation techniques, the encapsulation of hydrophilic drugs with high entrapment efficiency has been a problem, as the commonly used technique like single emulsification technique and w/o/w double emulsification technique show low entrapment of the hydrophilic drugs. The problem is overcome by using by using w/o/o double emulsification technique, several modifications have been done in this technique one of most widely and effective technique in w/o/o double emulsification is the solvent diffusion technique. In this brief review comparison of w/o/o double emulsification technique with other methods and details about the w/o/o double emulsification technique and the drugs encapsulated using this technique will be discussed.enMicrospheresw/o/ww/o/o etcArticle