Balaraman, KKuppusamy, MGeorge, NAnandkumar, KSekar, C1991-08-012009-05-271991-08-012009-05-271991-08-01Balaraman K, Kuppusamy M, George N, Anandkumar K, Sekar C. Evaluation of cyclosporine-A obtained from Tolypocladium sp. for immunosuppressive potential. Indian Journal of Medical Research. 1991 Aug; 94(): 304-6http://imsear.searo.who.int/handle/123456789/21689Cyclosporine-A obtained from an indigenous isolate of Tolypocladium sp. was evaluated for immunosuppressive potential by skin grafting in rats using the commercially available Sandimmune as reference at 15 and 30 mg/kg/day for a period of 14 days. The Sandimmune treated animal group showed 83 per cent acceptance of skin grafts while the test preparation treated group showed 67-83 per cent acceptance. The degree of nephro- and hepatotoxicity was comparable for both the preparations.engAnimalsCyclosporine --pharmacologyFemaleGraft Rejection --drug effectsMaleMitosporic Fungi --chemistryRatsSkin TransplantationJournal Article