Adeyemi, Oluyomi StephenAyonote, Divine AyebakuroOluwakemi, Josephine AwakanOlubunmi, AtolaniOpeyemi, AdejumoAdewole, IbrahimDamilare, RotimiGaber, El-Saber BatihaJohn, Olusegun Ojediran2020-10-162020-10-162020-05Adeyemi Oluyomi Stephen, Ayonote Divine Ayebakuro, Oluwakemi Josephine Awakan, Olubunmi Atolani, Opeyemi Adejumo, Adewole Ibrahim, Damilare Rotimi, Gaber El-Saber Batiha, John Olusegun Ojediran. Comparative evaluation of the antioxidant capacity of ferulic acid and synthesized propionyl ferulate. Journal of Applied Pharmaceutical Science. 2020 May; 2020 May: 097-1032231-3354http://imsear.searo.who.int/handle/123456789/210754Ferulic acid (FA) is a polyphenolic compound with demonstrated antioxidant capacity. In this study, propionylferulate (PF) was synthesized and characterized using melting point, ultraviolet spectroscopy, Fourier-transforminfrared spectroscopy, and mass spectrometry. The propionyl ferulate was comparatively evaluated for antioxidantpotential which included the ability to quench reactive species of 2,2-diphenyl-2-picrazyl-hydrazyl (DPPH), hydroxyl,nitric oxide, and superoxide anion. In addition, the total antioxidant capacity and membrane stabilizing properties ofthe ferulate were determined. Comparatively, the spectroscopically characterized PF showed superior scavengingcapacity for the DPPH, hydroxyl, and nitric oxide free radicals when compared to FA. On the contrary, PF showed apoor scavenging capacity for superoxide anion radicals. Furthermore, PF showed little or no potential for membranestability. In conclusion, the data suggest that structurally modifying FA to PF improved the antioxidant capacity forseveral free radicals.Antioxidantsfood additivesmedicinal chemistrymedicinal biochemistrynatural products.Journal ArticleIndiaDepartment of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran – 251101, NigeriaDepartment of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran – 251101, NigeriaDepartment of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran – 251101, NigeriaDepartment of Chemistry, University of Ilorin, PMB 1515, Ilorin, NigeriaDepartment of Chemistry, University of Ilorin, PMB 1515, Ilorin, NigeriaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Egypt.Department of Agricultural & Biosystem Engineering, Landmark University, PMB 1001, Omu-Aran – 251101, Nigeria