Kiran, RVarma, M N2009-05-282009-05-281990-07-01Kiran R, Varma MN. Age related toxic effects of endosulfan on certain enzymes of rat erythrocytes. Indian Journal of Experimental Biology. 1990 Jul; 28(7): 694-6http://imsear.searo.who.int/handle/123456789/57591The effect of oral administration of endosulfan (12.5 mg/kg body weight), daily for 4 days was investigated on erythrocytes of female rats of 4 different age groups i.e. 15, 30, 70 and 365 days old. Erythrocyte membrane Na+, K(+)-ATPase and Mg2(+)-ATPase activities were significantly inhibited in all the age groups of rats. However, percent inhibition was maximum in the youngest animals. A significant decrease in the activity of erythrocyte glutathione reductase was observed in 30 and 70 days old rats whereas a significant increase in the activity of glucose-6-phosphate dehydrogenase (G-6-PD) was observed in these groups. The increase in G-6-PD activity may be a physiological response to compensate for decrease in the reduced glutathione level which results from decrease in the activity of glutathione reductase.engAge FactorsAging --bloodAnimalsCell Membrane Permeability --drug effectsDrug ResistanceEndosulfan --pharmacologyErythrocytes --drug effectsGlutathione --bloodRatsComparative Study