Pugalendhi, K VSudhakaran, P RRamakrishnan, S2009-05-282009-05-281992-02-01Pugalendhi KV, Sudhakaran PR, Ramakrishnan S. Effect of antimicrobials on cholesterol synthesis and content in liver and small intestines. Indian Journal of Experimental Biology. 1992 Feb; 30(2): 152-4http://imsear.searo.who.int/handle/123456789/63051The antimicrobials tetracycline, ampicillin and bactrim (cotrimoxazole) decreased HMG CoA reductase activity in liver and small intestines of albino rats. Diminished incorporation of 1, 2, 14C acetate into cholesterol of small intestines in bactrim group was noted. There was a significant fall in cholesterol content of liver, duodenum, jejunum and ileum of the bactrim group and jejunum only in tetracycline group.engAmpicillin --pharmacologyAnimalsCholesterol --biosynthesisHydroxymethylglutaryl CoA Reductases --metabolismIntestine, Small --drug effectsLiver --drug effectsRatsTetracycline --pharmacologyTrimethoprim-Sulfamethoxazole Combination --pharmacologyJournal Article