Pal, Ritesh RanjanDas, BhabatoshDasgupta, ShreyaBhadra, Rupak K2011-11-212011-11-212011-02Pal Ritesh Ranjan, Das Bhabatosh, Dasgupta Shreya, Bhadra Rupak K. Genetic components of stringent response in Vibrio cholerae. Indian Journal of Medical Research. 2011 Feb; 133(2): 212-217.http://imsear.searo.who.int/handle/123456789/135374Nutritional stress elicits stringent response in bacteria involving modulation of expression of several genes. This is mainly triggered by the intracellular accumulation of two small molecules, namely, guanosine 3’-diphosphate 5’-triphosphate and guanosine 3’,5’-bis(diphosphate), collectively called (p)ppGpp. Like in other Gram-negative bacteria, the cellular level of (p)ppGpp is maintained in Vibrio cholerae, the causative bacterial pathogen of the disease cholera, by the products of two genes relA and spoT. However, apart from relA and spoT, a novel gene relV has recently been identified in V. cholerae, the product of which has been shown to be involved in (p)ppGpp synthesis under glucose or fatty acid starvation in a ΔrelA ΔspoT mutant background. Furthermore, the GTP binding essential protein CgtA and a non-DNA binding transcription factor DksA also seem to play several important roles in modulating stringent response and regulation of other genes in this pathogen. The present review briefly discusses about the role of all these genes mainly in the management of stringent response in V. cholerae.encgtAdksA(p)ppGpprelAspoTstringent responseVibrio choleraeAmino Acid SequenceCholera --microbiologyGene Expression Regulation, BacterialGenes, BacterialMolecular Sequence DataSequence AlignmentVibrio cholerae --geneticsVibrio cholerae --metabolismArticle